|
|
University of Potsdam, Germany |
The research focus of the group of Dr Zoran Nikoloski is the development of approaches for integration and analysis of ‚omics‘ data from high-throughput technologies in combination with the existing biological knowledge, structured in a form of ontologies and large-scale networks, in order to glean the design principles of biological processes. The resulting approaches are used to obtain insights into genotype-to-phenotype mapping via (1) data-driven qualitative and quantitative modelling of genome-scale metabolic and gene-regulatory networks, (2) analysis of evolutionary and optimisation processes in biological networks, and (3) characterization of system’s functions emerging from molecular interactions. Methods include network optimisation, design and analysis of algorithms, mathematical programming, and multivariate statistical approaches.